化学合成。
化学合成
合成路线 1（1. 合成：637336-53-9）
产率：96%
合成条件：With hydrogen In methanol for 24 h;
实验步骤：[1-METHYL-4-NITRO-LH-PYRAZOLE-3-CARBOXYLIC]酸甲酯（500mg，2.7mmol）和10％钯碳[（50mg））在甲醇[（25）mL）中的混合物， 在Parr装置中经受60psi的氢气压力24小时。 此时，将反应混合物通过硅藻土垫过滤并用甲醇洗涤。 将滤液真空浓缩，得到[4-AMINO-1-METHYL-LH-吡唑-3-]羧酸甲酯（402mg，96％），为灰白色固体。
参考文献：
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