633-35-2 雄甾-1,4,6-三烯-3,17-二酮

WGK Germany:3 RTECS号:BV8082250

• 生物活性 Androsta-1,4,6-triene-3,17-dione 是亲脂性、特异性的芳香酶 (aromatase) 抑制剂，Ki 值为 0.18 μM。Androsta-1,4,6-triene-3,17-dione 可抑制雌激素生物合成，具有避孕作用。Androsta-1,4,6-triene-3,17-dione 能诱导空间记忆障碍。
• 靶点 Ki: 0.18 μM (aromatase)
• 体内研究 Androsta-1,4,6-triene-3,17-dione (25-100 mg/kg; s.c.) prevents the normal rise in ovarian estradiol concentrations. Androsta-1,4,6-triene-3,17-dione may act in vivo to inhibit fertility by inhibition of estrogen biosynthesis . Animal Model: Rats (220-250 g) Dosage: 25 mg/kg, 100 mg/kg Administration: Subcutaneous injection Result: Prevented the normal rise in ovarian estradiol concentrations with a single injection 3 hours before the time of the estrogen surge on proestrus.

医药