化学合成。
医药
合成路线 1（1. 合成：446273-59-2）
产率：81.7%
合成条件：With bromine; sodium hydrogencarbonate In methanol at 0 - 20℃;
实验步骤：向CH 3 H（2000mL）中的3-氨基-6-氯哒嗪（[CAS 5469-69-2]，（200g，1538mmol）和NaHCO 3（258g，3076mmol）的溶液中加入Br 2（[CAS 7726-] 在0℃下滴加95-6]，369g，2308mmol），将混合物在室温下搅拌过夜，然后加入水（2000mL），过滤固体沉淀物并用水洗涤，将固体真空干燥，得到中间体。 1（260克，81.7％）。
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