化学合成。
化学合成
合成路线 1（1. 合成：161117-88-0）
产率：80%
合成条件：With dmap In dichloromethane at 20℃; Inert atmosphere
实验步骤：在氮气氛下将5-硝基吡啶-2-胺（1当量），Boc 2 O（1.2当量），DMAP（0.2当量）加入到aflask中。 在室温下加入二氯甲烷并将混合物搅拌过夜。 向粗品中加入乙酸乙酯，过滤沉淀物并用乙酸乙酯洗涤，得到所需的叔丁基（5-n itropyrid in-2- yl）carbam ate.HPLC-MS（方法A）：Rt = 2.88mm ，[M + H] + m / z：240。产量：80％。
参考文献：
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