3-甲磺酰氧基吡咯烷-1-羧酸叔丁酯是一种有机合成中间体，广泛应用于医药领域的相关化合物合成。
医药
合成路线 1（1. 合成：141699-57-2）
产率：100%
合成条件：With triethylamine In dichloromethane at 0 - 20℃; for 2.50 h;
实验步骤：向搅拌的3-羟基吡咯烷-1-羧酸叔丁酯（16g，85.4mmol）和三乙胺（19mL，129mmol）在130mL CH 2 Cl 2中的溶液中加入甲磺酰氯（10mL，129mmol）在20mL CH 2 Cl 2中的溶液。 在0°C下滴加。 添加后，将反应物在室温下搅拌2.5小时，然后用饱和NaHCO 3水溶液淬灭。 NaHCO 3（水溶液），并用CH 2 Cl 2萃取。 将萃取液干燥并浓缩，得到所需产物（22.7g，100％收率），为黄色固体。
参考文献：
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合成路线 2（2. 合成：141699-57-2）
产率：63.5%
合成条件：With triethylamine In dichloromethane at 0℃; for 3.50 h;
实验步骤：叔丁基-3 - [（甲基磺酰基）氧基]吡咯烷-1-羧酸酯; 将5-羟基吡咯烷-1-羧酸叔丁酯（3.00g，16.02mmol）溶于无水DCM（50mL）中并在冰水浴中冷却。 加入甲磺酰氯（2.38g，20.83mmol），然后加入TEA（2.43g，24.03mmol），将反应混合物在0℃下搅拌3.5小时。 将反应混合物用水（250mL）洗涤，用MgSO 4干燥，过滤并蒸发。 使用Biotage Horizon HPFC系统10（40 + M柱，等度运行的庚烷/ EtOAc（50:50））纯化粗产物，得到标题化合物（2.7g，63.5％）。 1H NMR（500MHz，CDCl3）：δ1.38（s，9H），2.07（bs，1H），2.18（bs，1H），2.97（s，3H），3.35-3.61（m，4H），5.16-5.18（ m，IH）; 13 C NMR（125MHz，CDCl 3）：δ28.59,31.84,32.76,38.80,43.61,52.16,80.12,154.30。
参考文献：
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