体内研究
Anitrazafen is a topically effective antiinflammatory agent. The disposition of
14
C in normal and in bile-duct cannulated rats after oral administration of a single dose of 25 mg/kg of [3-
14
C]Anitrazafen shows the drug to be well absorbed from the gastro-intestinal tract and biliary excretion to be the major route of elimination of drug and/or metabolites. Plasma concentrations of total
14
C after subcutaneous administration of [3-
14
C]Anitrazafen in corn oil solution are about one half those found after oral administration.
