87184-80-3 5-(叔丁基二甲基硅氧基)戊醛

作为医药中间体，用于抗生素、药物分子合成等医药相关研究。

医药

合成路线 1（1. 合成：87184-80-3）

产率：91% 合成条件：With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; potassium bromide In dichloromethane; water at 5 - 15℃; for 1 h; 实验步骤：5）5-（叔丁基 - 二甲基 - 硅烷氧基） - 戊醛的制备;向5-（叔丁基 - 二甲基 - 硅烷氧基） - 戊醇（16.8mmol，3.66g）的二氯甲烷（30mL）溶液中加入水（5.6mL），溴化钾（1.7mmol，202mg），n-在室温下，四丁基硫酸氢铵（0.84mmol，290mg）和TEMPO（30mg）。将得到的浅棕色溶液冷却至5℃并在该温度下滴加次氯酸钠（19.3mmol，30mL，5％）的溶液。加入一半次氯酸钠溶液后，加入固体碳酸钾（300mg）使反应混合物保持碱性。然后，在5-10℃下加入剩余的次氯酸钠溶液。此时，形成沉淀，并将反应混合物在10-15℃下再搅拌1小时。然后，加入水（100mL）。将得到的溶液萃取到乙醚（2.x.100mL）中。合并的有机萃取液用盐水溶液（150mL）洗涤，有机层用无水硫酸镁干燥。过滤干燥剂并除去溶剂，得到5-（叔丁基 - 二甲基 - 硅烷氧基） - 戊醛（3.32g，91％），为浅棕色油状物：ES（+） - HRMS m / e计算C11H24O2Si（ M + H）+ 217.1619，发现217.1619。 参考文献：

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