用于医药相关反应（如有机合成中间体）
医药
合成路线 1（1. 合成：62921-76-0）
产率：99%
合成条件：With sodium hydroxide In tetrahydrofuran; water at 0℃; for 5 h;
实验步骤：例37; 1-氯-2,2,5,5-四甲基-3-（2,5,8,11-四氧杂十三烷-13-基）咪唑烷-4-酮（化合物39-12）HN NHNaH2,5,8， 11-四氧杂三嗪-13-基4-甲基苯磺酸酯-0- -O- -o ^向四乙二醇单甲酯（工业级，Aldrich，10g，48mmol）在27ml四氢呋喃中的溶液中加入溶液 氢氧化钠水溶液（5M，27ml，134mmol）。 将溶液冷却至0℃，并将甲苯磺酰氯（16.5g，86.4mmol）在27mL THF中的溶液滴加到冷搅拌溶液中。 将反应混合物在0℃下搅拌5小时，然后用50mL水稀释，用二氯甲烷萃取两次。 将有机部分用水洗涤两次并用盐水洗涤一次，然后经硫酸镁干燥并在减压下浓缩，得到澄清液体（17.1g，47.1mmol，99％），粗产物不经纯化直接使用。 LRMS（ESI / APCI）m / z 363 [M + H] +。
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