10389-51-2 4-(4-硝基苯基)吗啉

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合成路线 3（3. 合成：10389-51-2）

产率：98% 合成条件：With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 6 h; Inert atmosphere 实验步骤：一般步骤：将芳基卤化物（1.0mmol），胺（1.5-2.0mmol），PNP-SSS（0.6mol％; 0.023g），K 2 CO 3（2mmol）和DMF（3.0mL）置于装有磁性的25mL烧瓶中 搅拌棒并在氮气下在120℃下加热。 然后通过TLC监测反应，直至检测到芳基卤的消耗。 反应完成后，向反应混合物中加入5mL水和5mL乙酸乙酯。 萃取有机溶液并经无水Na 2 SO 4干燥。 除去有机溶剂后，得到粗产物。 为了进一步纯化，使用色谱技术。 参考文献：

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