4-氯-6-硝基喹唑啉主要作为医药合成中间体，用于制备各类含喹唑啉结构的药物分子，在抗疟、抗肿瘤等药物研发中具有重要应用。
医药中间体
合成路线 1（1. 合成：19815-16-8）
产率：93.5%
合成条件：at 90℃; for 3 h;
实验步骤：将4-羟基-6-硝基喹唑啉（化合物5）（3.8g，0.02mol）置于100ml烧瓶中，缓慢加入40ml亚硫酰氯和1ml N，N-二甲基甲酰胺。 将混合物加热至90℃，使固体完全溶解，反应进行3小时（此时发现检测完全），减压蒸发亚硫酰氯，得到棕色固体4 - 氯-6-硝基喹唑啉（化合物6）3.92。 g，产率93.5％，HPLC纯度99.67％。 HNMR（300MHz，CDCl3）89.56（s，1H），8.39（d，J = 1.5Hz 1H），8.76（d，J = 1.5Hz，J = 6.0Hz，1H），8.77（d，J = 6.0Hz，1H）。
参考文献：
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合成路线 2（2. 合成：19815-16-8）
产率：87.2%
合成条件：at 160℃; for 3 h;
实验步骤：步骤14-氯-6-硝基 - 喹唑啉-6-硝基-3H-喹唑啉-4-酮4a（18.88g，99.40mmol）溶解在磷酰氯（31.03g，149mmol）中。将混合物温热至160℃。 搅拌3小时。将反应混合物加入250mL正己烷中，同时加热，搅拌，从溶液中沉淀出大量固体，过滤，用正己烷洗涤滤饼，真空干燥。 得到标题化合物4-氯-6-硝基 - 喹唑啉4b（18.14g，收率87.2％），为黄色固体。
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