2-乙酰胺基苯并噻唑-6-硼酸主要用于医药领域，作为有机合成中间体或药物研发的关键原料。
医药
合成路线 1（1. 合成：885069-14-7）
产率：97%
合成条件：With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In dimethyl sulfoxide at 90℃; for 8 h; Inert atmosphere
实验步骤：N-（6-溴苯并[d]噻唑-2-基）乙酰胺（2.10g，7.75mmol），双（频哪醇合）二硼（3.00g，11.8mmol），Pd（dppf）Cl2（560mg，0.77）的混合物 将该KOAc（3.00g，30.6mmol）和DMSO（50mL）在N 2气氛下在90℃下搅拌8小时。 冷却至室温后，过滤混合物。 将滤液用乙酸乙酯（200mL）稀释，用盐水（20mL×3）洗涤，经Na 2 SO 4干燥并浓缩。 将所得残余物用石油醚（50mL）洗涤，得到浅棕色固体（2.40g，97％）。
参考文献：
- [1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 17, p. 3665 - 3670 [2] Patent: WO2018/17435, 2018, A1. Location in patent: Paragraph 0092-0093 [3] Patent: CN107753483, 2018, A. Location in patent: Paragraph 0036; 0038; 0041-0042 [4] Patent: US2015/225407, 2015, A1. Location in patent: Paragraph 0410 [5] Patent: WO2010/100144, 2010, A1. Location in patent: Page/Page column 101-102 [6] Patent: US2012/202785, 2012, A1. Location in patent: Page/Page column 261 [7] Patent: WO2009/133127, 2009, A1. Location in patent: Page/Page column 84 [8] Patent: WO2009/129211, 2009, A1. Location in patent: Page/Page column 32 [9] Patent: EP2426135, 2012, A1. Location in patent: Page/Page column 112 [10] Journal of Medicinal Chemistry, 2015, vol. 58, # 1, p. 517 - 521 [11] Patent: WO2009/17822, 2009, A2. Location in patent: Page/Page column 52; 53 [12] Journal of Medicinal Chemistry, 2011, vol. 54, # 6, p. 1789 - 1811 [13] Patent: WO2014/151147, 2014, A1. Location in patent: Paragraph 00514 [14] Patent: US9174994, 2015, B2. Location in patent: Page/Page column 126; 127 [15] Patent: WO2017/219800, 2017, A1. Location in patent: Paragraph 00164; 00165
