885069-14-7 2-乙酰胺基苯并噻唑-6-硼酸频哪醇酯

2-乙酰胺基苯并噻唑-6-硼酸主要用于医药领域，作为有机合成中间体或药物研发的关键原料。

医药

合成路线 1（1. 合成：885069-14-7）

产率：97% 合成条件：With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In dimethyl sulfoxide at 90℃; for 8 h; Inert atmosphere 实验步骤：N-（6-溴苯并[d]噻唑-2-基）乙酰胺（2.10g，7.75mmol），双（频哪醇合）二硼（3.00g，11.8mmol），Pd（dppf）Cl2（560mg，0.77）的混合物 将该KOAc（3.00g，30.6mmol）和DMSO（50mL）在N 2气氛下在90℃下搅拌8小时。 冷却至室温后，过滤混合物。 将滤液用乙酸乙酯（200mL）稀释，用盐水（20mL×3）洗涤，经Na 2 SO 4干燥并浓缩。 将所得残余物用石油醚（50mL）洗涤，得到浅棕色固体（2.40g，97％）。 参考文献：

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