化学合成。
化学合成
合成路线 1（1. 合成：83942-10-3）
产率：88.5%
合成条件：With trichlorophosphate In tolueneReflux
实验步骤：2）中间体4,5-二氯-6-甲基嘧啶的制备将50ml POCl 3滴加到14.5g（0.1mol）4-羟基-5-氯-6-甲基嘧啶在50mL甲苯中的溶液中， 加入后将混合物回流5-7小时。 通过薄层色谱监测反应结束后，将反应混合物减压浓缩除去甲苯和额外的POCl 3，然后倒入冰水中。 用乙酸乙酯（3×50ml）萃取水相，出现有机相，用无水硫酸镁干燥，过滤，然后减压浓缩。 通过二氧化硅柱纯化残余物，得到14.43g，为黄色液体，产率为88.5％。
参考文献：
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