体内研究
Isocarboxazid (1, 3 mg/kg, i.p., 60 min) pretreatment in mice shows the significant increased number of head twitches at 15 and 30 min after 5-HTP.
Isocarboxazid (1, 3 mg/kg, i.p., 60 min) treatment in mice together with 5-HTP administration causes 43% 5-HT concentration increased and 22% of 5-HIAA decreased compared to brain concentrations in mice given 5-HTP alone.
Animal Model:
Twelve male mice of
dd
strain (20-25 g)
Dosage:
0, 0.3,1, 3 mg/kg
Administration:
Intraperitoneally 60 min before intravenous injection of 5-HTP
Result:
The number of head twitches at 15 and 30 min after 5-HTP was increased.
43% 5-HT concentration increased and 22% of 5-HIAA decreased.
