作为医药中间体，用于相关药物的合成研究。
医药
合成路线 1（1. 合成：17090-15-2）
产率：95%
合成条件：With sodium hydrogencarbonate In acetonitrile at 0℃; for 0.50 h;
实验步骤：在0℃下，将丙烯酰氯（3.7mL，45.61mmol）滴加到化合物14（6.0g，43.44mmol）和碳酸氢钠（5.5g，65.16mmol）的乙腈（30mL）溶液中。 搅拌反应0.5小时。 将反应混合物加入水（300mL）中。 过滤沉淀物，滤出的滤饼用另外的水冲洗并在真空烘箱中干燥，得到白色固体（7.9g，95％）。
参考文献：
- [1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 21, p. 5505 - 5512 [2] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 444 - 455 [3] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 14, p. 4179 - 4186 [4] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 2, p. 765 - 772 [5] European Journal of Medicinal Chemistry, 2018, vol. 143, p. 1847 - 1857 [6] Patent: CN106432239, 2017, A. Location in patent: Paragraph 0066; 0067; 0068 [7] Patent: WO2018/4306, 2018, A1. Location in patent: Page/Page column 49 [8] Patent: CN105384695, 2016, A. Location in patent: Paragraph 0179; 0180; 0181; 0182; 0183; 0184 [9] Patent: WO2016/138527, 2016, A1. Location in patent: Paragraph 00368 [10] Patent: WO2018/88780, 2018, A1. Location in patent: Page/Page column 14 [11] Patent: WO2013/107405, 2013, A1. Location in patent: Page/Page column 74 [12] Patent: US2015/87600, 2015, A1. Location in patent: Page/Page column [13] Patent: US2007/37862, 2007, A1 [14] Patent: WO2015/3658, 2015, A1. Location in patent: Page/Page column 43; 44 [15] Journal of Medicinal Chemistry, 2015, vol. 58, # 23, p. 9171 - 9178 [16] Patent: CN106554318, 2017, A. Location in patent: Paragraph 0095; 0096; 0097; 0098; 0099 [17] Patent: CN106749042, 2017, A. Location in patent: Paragraph 0079; 0080; 0081; 0082; 0083 [18] Patent: CN106905245, 2017, A. Location in patent: Paragraph 0144; 0145; 0146; 0147; 0148 [19] Patent: CN106565782, 2017, A. Location in patent: Paragraph 0067; 0068; 0069 [20] Patent: US4165365, 1979, A [21] Patent: CN108586454, 2018, A. Location in patent: Paragraph 0134; 0144; 0145 [22] Patent: CN108610295, 2018, A. Location in patent: Paragraph 0028; 0034; 0036; 0038
合成路线 2
产率：62.3%
合成条件：With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 1 h;
实验步骤：通用方法：将2-氟-N-甲基-5-硝基苯胺（11.0g，64.7mmol）和DIPEA（23mL，129.4mmol）溶于100mL THF中，在室温下搅拌。 然后加入丙烯酰氯（11mL，129.4mmol）溶液。 然后将反应混合物在室温下搅拌1小时以蒸馏出大部分溶剂，然后用100mL乙酸乙酯稀释，用饱和盐水洗涤，干燥，过滤并减压蒸发，得到黄色油状物N-（ 2-氟-5-硝基苯基）-N-甲基丙烯酰胺（12.0g，收率83％）。
参考文献：
