105355-26-8 2-氨基-5-(4-(2-(5-乙基吡啶-2-基)乙氧基)苄基)噻唑-4(5H)-酮

中文名称: 2-氨基-5-(4-(2-(5-乙基吡啶-2-基)乙氧基)苄基)噻唑-4(5H)-酮
英文名称: 2-Amino-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzyl)thiazol-4(5H)-one
CAS号
分子式: C₁₉H₂₁N₃O₂S
分子量: 355.45
更新日期: 2026-06-23

名称和标识

中文名: 2-氨基-5-(4-(2-(5-乙基吡啶-2-基)乙氧基)苄基)噻唑-4(5H)-酮
英文名: 2-Amino-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzyl)thiazol-4(5H)-one
CAS号: 105355-26-8
分子式: C19H21N3O2S
分子量: 355.45
中文别名: 吡格列酮亚氨基杂质; 5-{4-[2-(5-乙基-2-吡啶基)-乙氧基]-苄基}-2-亚氨基-4-噻唑烷酮; 吡格列酮亚胺杂质; 2-氨基-5-[4-[2-(5-乙基-2-吡啶基)乙氧基]苯甲基]噻唑-4(5H)-酮; 盐酸吡格列酮/5-{4-[2-(5-乙基-2-吡啶基)-乙氧基]-苄基}-2-亚胺基-4-噻唑烷酮; 吡咯列酮亚胺; 2-氨基-5-[4-[2-(5-乙基-2-氮苯基)乙氧基]苯基]噻唑-4(5H)-酮; 亚氨基匹格列酮
英文别名: Pioglitazone Imino Impurity; 2-AMINO-5-[4-[2-(5-ETHYL-2-PYRIDYL)ETHOXY]BENZYL]-4(5H)-THIAZOLONE; 2-AMINO-5-(4-[2-(5-ETHYL-PYRIDIN-2-YL)-ETHOXY]-BENZYL)-THIAZOL-4-ONE; 5-{4-[2-(5-ETHYL-2-PYRIDYL)ETHOXY]BENZYL}-2-AMINO-4-THIAZOLIDINONE; 5-{4-[2-(5-ETHYL-2-PYRIDYL)ETHOXY]BENZYL}-2-IMINO-4-THIAZOLIDINONE(FOR PIOGLITAZONE); Imino-Pioglitazone; (5-{4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl}-2-imino-4-thiazolidone); 4(5H)-Thiazolone,2-amino-5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-; 5-{[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methy}-2-imino-4-thiazolidinone; Pioglitazone 2-Imine; 2-Amino-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazol-4(5H)-one; 5-{4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl}-2-imino-4-thiazolidinone; 5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]-2-imino-4-thiazolidinone; 5-{4-[5-(ethylpyridin-2-yl)ethoxy]benzyl}-2-iminothiazolidin-4-one; 5-{4-[2-(5-Ethylpyridin-2-yl)ethoxy]benzyl}-2-imino-1,3-thiazolidin-4-one; 2-Amino-5-{4-[2-(5-ethyl-2-pyridinyl)ethoxy]benzyl}-1,3-thiazol-4(5H)-one; Pioglitazone Impurity 14

物化属性

Aromatic Heavy Atoms: 12
BBB Permeant: No
Bioavailability Score: 0.55
CYP1A2 Inhibitor: No
CYP2C19 Inhibitor: Yes
CYP2C9 Inhibitor: Yes
CYP2D6 Inhibitor: Yes
CYP3A4 Inhibitor: Yes
GI Absorption: High
Heavy Atoms: 25
Hydrogen Bond Acceptors: 4.0
Hydrogen Bond Donors: 1.0
LogP: 2.57
MLOGP: 2.41
Molar Refractivity: 104.58
P-gp Substrate: No
PSA: 102.87 Å²
Rotatable Bonds: 7
SILICOS-IT LogP: 4.52
Skin Permeation Log Kp: -6.03 cm/s
Storage Condition: Refrigerator
Synthetic Accessibility: 3.77
WLOGP: 2.38
XLogP3: 3.43
iLOGP: 2.69
外观: White to Light yellow to Light orange powder to crystalline
密度: 1.3±0.1 g/cm³
折射率: 1.646
沸点: 557.4±60.0 °C (760 mmHg)
溶解度: 可溶于DMSO（略微加热）、甲醇（略微加热）
熔点: 187-188 °C
精确质量: 355.135437
蒸汽压: 0.0±1.5 mmHg (25 °C)
酸度系数(pKa): 5.53±0.22
闪点: 290.9±32.9 °C

安全信息

安全说明

危险性质：非危险化学品

生产及用途

用途与制备

有机、医药合成中间体，可用于合成盐酸吡格列酮。

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