化学合成。
化学合成
合成路线 1（1. 合成：7306-68-5）
产率：99.3%
合成条件：With toluene-4-sulfonic acid In ethyl acetate at 90℃; for 1 h;
实验步骤：将6-氯-9H-嘌呤（25.36g，164mmol）和4-甲基苯磺酸（0.565g，3.28mmol）的EtOAc（250mL）悬浮液用3,4-二氢-2H-吡喃（44.9mL）处理 ，492mmol）。 将混合物在90℃下加热，并将固体在1小时内缓慢溶解。 从油浴中取出烧瓶，过滤混浊的黄色溶液并真空浓缩。 将浅黄色残余物溶于DCM中，并通过快速色谱法（50％EtOAc /己烷）（1L二氧化硅/ 4L溶剂）纯化，得到6-氯-9-（四氢-2H-吡喃-2-基）-9H-嘌呤。 （38.90g，99.3％收率），为无色油状物，其缓慢结晶。 MS（ESI，阳离子）m / z：239.1 [M + H] +
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