382180-17-8 N1-羟基-N8-(吡啶-3-基)辛二酰胺

危险性质：非危险化学品

• 生物活性 Pyroxamide 是一种有效的组蛋白脱乙酰基酶 1 (HDAC1) 抑制剂，ID50 为 100 nM。 Pyroxamide 可以诱导白血病细胞凋亡和细胞周期停滞。
• 靶点 ID50: 100 nM
• 体外研究 Pyroxamide (1.25-20.0 μM; 24-72 hours) suppresses RD and RH30B cells growth, pyroxamide resulted in 44% dead cells for 72 h at 20.0 μM, results in 86% dead cells in culture. Pyroxamide (10.0-20.0 μM; 48 hours) shows sub-G1 fractions of 45.0% and 72.3% at 10.0 and 20.0 μM, respectively. Cell Viability Assay Cell Line: RD cells; RH30B cells Concentration: 1.25-20.0 μM Incubation Time: 24 hours; 48 hours; 72 hours Result: Resulted in a cell growth decrease in RD and RH30B cells. Cell Cycle Analysis Cell Line: RD cells; RH30B cells Concentration: 10.0 μM; 20.0 μM Incubation Time: 48 hours Result: Increased the sub-G1 fractions at 48 hours compared with control samples.

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