作为有机合成中间体，用于制备功能性材料或药物分子，在材料化学领域有潜在应用。
有机合成; 材料化学
合成路线 1（1. 合成：136630-36-9）
产率：85%
合成条件：With hydrogenchloride; tin In ethanol; water at 70℃; for 1 h; Inert atmosphere
实验步骤：（2）在氮气氛下，将化合物2（4.02g，10mmol）溶于48mL乙醇和30mL水溶液中，在搅拌下缓慢加入锡粉（5.94g，50mmol），然后加热至80℃。 在70℃下保持1小时，停止加热，将反应烧瓶放入冰水浴中，逐渐加入2mol / L氢氧化钠水溶液直至反应体系变为碱性。 然后用二氯甲烷萃取，收集有机相并用无水硫酸钠干燥。 通过硅胶柱色谱法分离产物，并使用石油醚和四氢呋喃（v / v，20/1）作为洗脱剂在真空中分离，使用1 H NMR得到85％收率的浅灰色固体。 确认黄色固体为化合物3
参考文献：
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合成路线 2（2. 合成：136630-36-9）
产率：81%
合成条件：Stage #1: With copper In N,N-dimethyl-formamide for 3 h; Reflux Stage #2: With hydrogenchloride; tin In water; N,N-dimethyl-formamide for 6 h; Cooling with ice
实验步骤：将2,5-二溴硝基苯（4.5g，16mmol）溶于N'N-二甲基甲酰胺中，加入铜粉（0.2g，3mmol），将该反应物在回流下搅拌3小时，冷却后，加入锡粉 加入（0.2g，1.7mmol），冰盐浴条件加入10ml盐酸，搅拌6小时，真空干燥蒸发溶剂，然后将固体溶解在乙酸乙酯中，搅拌，过滤，用饱和盐水洗涤3次， 在真空汽蒸下将溶剂蒸发至干，通过硅胶柱色谱法纯化，得到固体化合物23a（4.65g，13mmol），收率81％。
参考文献：
- [1] Organic Letters, 2003, vol. 5, # 7, p. 1131 - 1134 [2] Patent: CN106831633, 2017, A. Location in patent: Paragraph 0106; 0108; 0109 [3] Patent: CN105418486, 2016, A. Location in patent: Paragraph 0131; 0132; 0133 [4] Journal of Materials Chemistry, 2011, vol. 21, # 32, p. 11800 - 11814 [5] Journal of the American Chemical Society, 2014, vol. 136, # 32, p. 11276 - 11279 [6] Journal of Materials Chemistry C, 2015, vol. 3, # 11, p. 2624 - 2631 [7] Chemistry - An Asian Journal, 2015, vol. 10, # 10, p. 2134 - 2138 [8] Journal of Materials Chemistry C, 2015, vol. 3, # 26, p. 6822 - 6830 [9] Chemical Communications, 2016, vol. 52, # 21, p. 4022 - 4024 [10] Journal of Materials Chemistry A, 2016, vol. 4, # 22, p. 8750 - 8754 [11] Patent: CN103819455, 2016, B [12] Patent: US2017/69856, 2017, A1 [13] Patent: KR2015/34146, 2015, A [14] Patent: CN104311588, 2016, B [15] Journal of the American Chemical Society, 2018, vol. 140, # 24, p. 7611 - 7622 [16] Organic Electronics: physics, materials, applications, 2018, vol. 59, p. 77 - 83 [17] Journal of the American Chemical Society, 2018,
