化学合成。
化学合成
合成路线 1（1. 合成：21594-52-5）
产率：92%
合成条件：With N-Bromosuccinimide In N,N-dimethyl-formamide at 40℃; for 14 h; Autoclave; Large scale
实验步骤：在干燥的3000mL单颈圆底烧瓶中，加入1500mL乙腈和360mL乙酸，然后加入42. 8g 2,3-二氢吡啶并[2,3-d] [1， 3]酮。完全溶解后，分批加入64.2g NBS（N-溴代琥珀酰亚胺），将反应混合物在室温下搅拌14小时。通过TLC和GC确认反应完成后，加入20mL过二硫酸钠（24g）。通过旋转蒸发除去溶剂，向反应烧瓶中加入300mL水，用300mL乙基萃取混合物两次。合并有机相，用180mL 2N氢氧化钠洗涤，然后用300mL饱和盐水洗涤。用无水硫酸钠干燥过夜。过滤除去硫酸钠，减压蒸发得到粗产物。得到64.1g粗产物，为粗产物，6-溴-3H-恶唑烷[4,5-B]。粗产物用二氯甲烷和乙酸乙酯重结晶，得到纯产物6-溴-3H-恶唑并[4,5-b]吡啶-2-酮59.9g，收率89％。 2％（GC）。熔点231℃至234℃（文献232℃~233℃）。
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