化学合成。
医药
合成路线 1（1. 合成：177947-96-5）
产率：99%
合成条件：With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In ethyl acetateReflux
实验步骤：向在EA（500ml）中的3-（羟甲基）氮杂环丁烷-1-羧酸叔丁酯（20.96g，112mmol）的搅拌溶液中加入IBX（62.69g，224mmol）并将反应物回流过夜。 将反应冷却至室温，加入PE（500ml）并过滤反应混合物。 减压浓缩滤液，得到化合物1.3，为黄色油状产物（20.56g，99％）。 1 H NMR（400MHz，CDCl 3）δ5.144（s，9H），3.32-3.4015（m，1H），4.07-4.14（m，4H），9.85（d，J = 2.0Hz，3H）。
参考文献：
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