96574-01-5 丹酚酸A

WGK Germany:3 海关编码:29189900 存储类别:13 - 不可燃性固体

• 生物活性 Salvianolic acid A 可通过抑制基质金属钛酶 9 (MMP-9) 和抗炎作用来保护血脑屏障。
• 靶点 MMP-9
• 体内研究 A significant beneficial effect of Salvianolic acid A (SAA) is observed in the Salvianolic acid A treatment groups. Salvianolic acid A (20 mg/kg) could significantly prolonged the retention time of rats on the plate. While compared with sham operation group, the brain water content in model group significantly increases, which is attenuated significantly by Salvianolic acid A (10 and 20 mg/kg). Compared with the model group, Salvianolic acid A (5, 10, and 20 mg/kg) could maintain the normal structures of neurons and increase neurons number. It is also found that Salvianolic acid A (20 mg/kg) could significantly reduce I/R induced MMP-9 upregulation. While the MMP-2 expression is not significantly affected by Salvianolic acid A. Tissue inhibitors of metalloproteinases (TIMPs) could inhibit the activity of MMPs through high affinity binding to MMPs catalytic domain.
• 化学性质 黄色针状结晶，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于丹参根茎。
• 丹酚酸A适用于心绞痛及急性心肌梗塞，脑血栓形成的后遗症。
• 用于含量测定/鉴定/药理实验等。 药理药效:抗凝血作用和显著的抗血小板聚集作用，抗分泌和抗溃疡作用等。

医药

来源于丹参根茎，具体提取方法未明确说明。