化学合成。
医药; 有机合成
合成路线 1（1. 合成：133446-99-8）
产率：96%
合成条件：With N-Bromosuccinimide In tetrachloromethane for 2 h; Reflux
实验步骤：U）2-溴甲基-4-硝基 - 苯甲酸甲酯将N-溴代琥珀酰亚胺（2.18g，12.30mmol）加入搅拌的2-甲基-4-硝基 - 苯甲酸甲酯（2g，10.25mmol）溶液中。 在室温下ABCN（626mg，2.56mmol）的四氯化碳（80ml）溶液。 将反应加热回流2小时，然后冷却至室温并搅拌15小时。 真空蒸发溶剂，将得到的残余物通过二氧化硅垫过滤（用二氯甲烷洗脱）。 将溶剂真空蒸发，得到标题化合物，为黄色固体（2.70g，96％）。 HPLC保留时间4.49分钟。 质谱（ES +）m / z 256（M + H）。
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