473-08-5 α-香附酮

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名称和标识

中文名: α-香附酮
英文名: alpha-Cyperone
CAS号: 473-08-5
分子式: C15H22O
分子量: 218.33
中文别名: (4aS,7R)-1,4a-二甲基-7-(丙-1-烯-2-基)-4,4a,5,6,7,8-六氢萘-2(3H)-酮; (4aS,7R)-1,4a-二甲基-7-丙-1-烯-2-基-3,4,5,6,7,8-六氢萘-2-酮; A-香附酮; alpha-香附酮
英文别名: (4aS,7R)-1,4a-Dimethyl-7-(prop-1-en-2-yl)-4,4a,5,6,7,8-hexahydronaphthalen-2(3H)-one; (4aS,7R)-1,4a-dimethyl-7-prop-1-en-2-yl-3,4,5,6,7,8-hexahydronaphthalen-2-one; (4aS-cis)-4,4a,5,6,7,8-Hexahydro-1,4a-dimethyl-7-(1-methylethenyl)-2(3H)-naphthalenone; (4aS,7R)-7-Isopropenyl-1,4a-dimethyl-4,4a,5,6,7,8-hexahydro-2(3H)-naphthalenone; Eudesma-4,11-dien-3-one; Eudesma-4,11-dien-3-on; a-Cyperone; α-cyperon; α-cyperone

安全说明

WGK Germany:WGK 3 海关编码:29143990 存储类别:10 - 可燃性液体

用途与制备

简介 alpha-香附酮为黄色液体，易溶于甲醇、水，来源于香附，益智仁，莎草科植物香附(莎草) Cyperus rotundus L. 的根茎。
生物活性 α-Cyperone (alpha-cyperone) 是香附子Cyperus rotundus的主要活性成分，表现出了如抗毒力、抗原毒性和抗菌活性等生物活性。α-Cyperone (alpha-cyperone) 与COX-2、IL-6、Nck-2、Cdc42 和 Rac1 的表达下调有关。
靶点 Human Endogenous Metabolite
体外研究 The anti-inflammatory activity of alpha-Cyperone (α-Cyperone) is associated with the down-regulation of COX-2 and IL-6 via the negative regulation of the NFκB pathway in LPS-stimulated RAW 264.7 cells. alpha-Cyperone (α-Cyperone) binds and interacts with tubulin and is capable of distinctly destabilizing microtubule polymerization. The effect of this interaction could result in reduction of inflammation which would be highly beneficial for treatment of inflammatory diseases such as AD. One microliter of alpha-Cyperone was dissolved in DMSO (1:1 v/v) and it was further diluted in double distilled water (ddH2O) to a final volume of 20 microliter.
化学性质黄色液体，易溶于甲醇、水，来源于香附，益智仁，莎草科植物香附(莎草) Cyperus rotundus L. 的根茎。
α-香附酮具有解热镇痛的作用。
用于含量测定/鉴定/药理实验等药理药效:疏肝解郁，养血调经止痛

医药

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