化学合成。
化学合成
合成路线 1（1. 合成：95104-21-5）
产率：82%
合成条件：With ammonium hydroxide; ammonium cerium (IV) nitrate; hydroxylamine hydrochloride In water at 0℃;
实验步骤：将2-氯喹啉-3-甲醛（0.01mol）在30％氨水（30mL）中的悬浮液在室温下搅拌5分钟，导致形成混浊溶液。 在0℃恒定搅拌下向其中加入硝酸铈铵（0.01mol）。反应完成后（通过TLC监测，10-15分钟），用氯仿 - 乙酸乙酯（5：3）萃取混合物，用 用无水硫酸钠浓缩，减压浓缩，得到粗产物，将其用乙醇结晶，得到纯的2-氯喹啉-3-甲腈，为浅黄色晶体。 产量：82％。
参考文献：
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