化学合成。
医药
合成路线 1（1. 合成：1029413-55-5）
产率：78.7%
合成条件：With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; for 2 h;
实验步骤：步骤3）4-（4-氨基-1H-吡唑-1-基）哌啶-1-羧酸叔丁酯[0409] 4-（4-硝基-1H-吡唑-1-基）叔丁基酯的溶液 ）向哌啶-1-羧酸酯（1.35g，4.56mmol）的乙醇（30mL）溶液中加入Pd / C（135mg，1.269mmol，质量百分比= 10％）。 将混合物在H 2气氛下在室温下搅拌2小时。过滤所得混合物并将滤液真空浓缩。 通过硅胶柱色谱法（DCM / MeOH（v / v）= 50/1至25/1）纯化残余物，得到标题产物，为棕色油状物（955mg，产率78.7％）。 LC-MS（ESI，阳离子）m / z：211.1 [M-55] +。
参考文献：
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