生命科学。
生命科学; 生化试剂; 多肽合成
合成路线 1（1. 合成：2304-96-3）
产率：84%
合成条件：With sodium carbonate In 1,4-dioxane at 0 - 20℃; Inert atmosphere
实验步骤：在0℃下，向6.05g（0.45mmol）L-天冬酰胺在100mL 10％Na 2 CO 3中的溶液中加入56mL 1,4-二恶烷和6.9mL（0.04mmol）氯甲酸苄基酯。 将反应混合物在室温下搅拌过夜，并倒入300mL H 2 O中。 将混合物用乙醚洗涤三次。 用2N HCl水将水层酸化，析出白色沉淀。 滤出沉淀物并用乙醚充分洗涤，得到化合物14，为灰白色固体（9g，84％分离的产物）; MS（ESI）：m / z = 267 [M + H] +，289 [M + Na] +。
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