化学合成。
化学合成
合成路线 1（1. 合成：709652-82-4）
产率：100%
合成条件：at 20℃; for 0.50 h;
实验步骤：例1; 2-氨基-5-溴吡啶-3-甲腈（2）; 将2-氨基吡啶-3-甲腈1（0.56g，4.6mmol）溶于10mL HOAc中，向其中加入1当量的Na 2 CO 3。 然后，滴加1.1当量的Br 2并将反应混合物在室温下搅拌30分钟。 形成橙色沉淀并过滤，以定量收率得到所需化合物2。 该化合物无需进一步纯化即可使用。
参考文献：
- [1] Patent: WO2007/59219, 2007, A1. Location in patent: Page/Page column 54 [2] Chemical Papers, 2018, vol. 72, # 12, p. 2965 - 2972 [3] Patent: WO2013/29548, 2013, A1. Location in patent: Page/Page column 87 [4] Patent: US2014/179675, 2014, A1. Location in patent: Paragraph 0841 [5] Patent: US2016/311772, 2016, A1. Location in patent: Paragraph 1260-1263 [6] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 8, p. 710 - 714 [7] Patent: US2015/368241, 2015, A1. Location in patent: Paragraph 0116 [8] Patent: WO2014/78802, 2014, A1. Location in patent: Page/Page column 92; 93 [9] Patent: WO2004/52890, 2004, A1. Location in patent: Page 188 [10] Patent: WO2015/14442, 2015, A1. Location in patent: Page/Page column 54 [11] Tetrahedron Letters, 2014, vol. 55, # 36, p. 5058 - 5061 [12] Patent: WO2013/42035, 2013, A1. Location in patent: Page/Page column 17 [13] Patent: US2014/249170, 2014, A1. Location in patent: Paragraph 0067; 0068 [14] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 5, p. 507 - 512
