生命科学。
尼达尼布乙磺酸盐是一种一种酪氨酸激酶抑制剂,可用作原料药,用于治疗特发性肺纤维化(IPF)。
合成路线 1(1. 合成:656247-18-6)
产率:100%
合成条件:for 4 h; Reflux
实验步骤:依次加入3个25ml烧瓶,加入2.0g Trinidad Technip,7.5g乙磺酸,10ml甲醇加热回流,回流搅拌4h,停止加热,蒸发溶剂至干,得到的固体成浆,加入15ml丙酮, 抽滤,得到浅黄色固体2.4g,收率:100%。HPLC纯度:99.75%
参考文献:
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