125-13-3 3,3-二(4-羟基苯基)-2(3H)-吲哚酮

• 生物活性 Oxyphenisatine (Oxyphenisatin) 是一种泻药。 Oxyphenisatin acetate是具有抗癌活性的氧联苯沙星的前体药。
• 体外研究 Oxyphenisatin has been shown to have antiproliferative activity. Oxyphenisatin acetate (OXY, NSC 59687) is the pro-drug of oxyphenisatin. OXY inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468 (IC 50 =0.8, 0.6, 2.1, 1.8 μM). This effect is associated with selective inhibition of translation accompanied by rapid phosphorylation of the nutrient sensing eIF2α kinases, GCN2 and PERK.
• 体内研究 Toxicity studies demonstrate that mice tolerate IP administration of OXY at 300 mg/kg once daily or 200 mg/kg twice daily. Administration of OXY at 300 mg/kg IP once daily for 10 days results in significantly smaller tumors from day 33 to day 52.
• 化学性质 结晶。熔点 ＞260℃。
• 三醋酚汀的中间体。

医药

用靛红与苯酚在浓硫酸作用下缩合制得。