135304-07-3 N-乙酰基-S-法呢基-L-半胱氨酸

危险等级:IRRITANT

• 生物活性 Arazine (N-Acetyl-S-farnesyl-L-cysteine) 是 G 蛋白和 G 蛋白偶联受体 (G protein and G-protein coupled receptor) 信号传导的细胞渗透性调节剂。Arazine 可与异戊烯化的 G 蛋白或其受体位点竞争，成为异戊二烯基半胱氨酸甲基转移酶的底物。
• 体外研究 Arazine (2 hours) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner in HMEC-1 cell. Arazine (10–100 μM;8 hours) significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion in HMEC-1 cell.
• 体内研究 Arazine (AFC) (2,000 μg/20 μl; applied on ear) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with a 50% effective dose (ED 50 ) of 55±12 μg/20 μl. Animal Model: TPA-induced ear acute inflammation in mouse Dosage: 2000 μg/20 μl Administration: 2000 μg/20 μl; Applied on ear Result: Inhibited ear edema, as measured by ear weight.

医药