- 4-氟苯甲酰肼是一种有机中间体，可作为有机合成中间体和医药中间体，主要用于实验室研发过程和化工生产过程中。
- 制备
在250mL的三口瓶中加入对氟苯甲酸(10.0g，60mmol)和100mL四氢呋喃，再加入N,N'-羰基二咪唑(12.6g，78mmol)，TLC监测原料反应是否完全，反应完毕后，缓慢滴加80％水合肼(5.94g，95mmol)，滴毕，搅拌反应6小时左右。
TLC监测原料反应是否完全(展开剂：石油醚/乙酸乙酯1:1)。反应完毕后，冷至
室温，减压浓缩除去大部分有机溶剂，加水约30mL，室温下打浆片刻，抽滤，水洗，得白色片状固体。经15mL无水乙醇重结晶得4-氟苯甲酰肼，白色固体6.91g，收
率75.2％。
有机合成中间体; 医药中间体
合成路线 1（1. 合成：456-06-4）
产率：100%
合成条件：With hydrazine hydrate In ethanol at 20 - 85℃; for 10 h; Reflux
实验步骤：在室温下向搅拌的4-氟乙基苯甲酸酯（4.5g，26.7mmol）的EtOH（30mL）溶液中加入NH 2 NH 2 .H 2 O（6.67g，133.5mmol），并将溶液在85℃下回流10小时。 将反应冷却至室温，减压浓缩，用正己烷（50mL）洗涤固体，然后干燥，得到4-氟苯甲酰肼固体（4.2g，定量收率）。 1H NMR（400MHz，DMSO-d6）：δ9.85（s，1H），7.86（dd，2H），7.25（t，3H），4.46（s，1H），3.47（br s，1H）。
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合成路线 2（2. 合成：456-06-4）
产率：83%
合成条件：With hydrazine hydrate In methanol for 5 h; Reflux
实验步骤：通用方法：向适当的甲酯17（a-j）（1.0mmol）在50mL甲醇中的溶液中加入99％的水合肼（4.0mmol），将混合物回流5小时直至反应完成（TLC）。 反应完成后，冷却，用甲醇洗涤得到的固体。 粗产物用乙醇重结晶。
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