2-(1-苯基亚乙基)丙二腈主要用于医药和农药领域，其合成方法包括无溶剂条件下醛与活性亚甲基化合物反应及甲苯-乙酸铵体系回流反应，产物结构经NMR确认。
医药; 农药
合成路线 1（1. 合成：5447-87-0）
产率：92%
合成条件：With 1,2-ethanediammonium 3-hydroxypropane-1-sulfonate In neat (no solvent) at 60℃; for 3 h; Green chemistry
实验步骤：通用程序：将[（EDA）（HPS）]（10mol，0.0340g）在无溶剂条件下于60℃在搅拌的醛（1mmol）和活性亚甲基化合物（1.2mmol）的混合物中加入。 将反应混合物搅拌适当的时间（表2）。 通过TLC监测反应进程。 反应完成后，将温热的乙醇（5mL）加入到反应混合物中。 过滤有机催化剂并用温乙醇（2×10mL）完全洗涤，然后在室温下干燥。 减压蒸发剩余溶液中的溶剂，得到粗产物。 通过在含水乙醇中重结晶获得纯产物。
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