化学合成。
化学合成
合成路线 1（1. 合成：20099-90-5）
产率：80%
合成条件：With bromine In acetic acid at 20℃; for 4 h; Inert atmosphere
实验步骤：一般步骤：将1mmol所需的苯乙酮溶于10mL AcOH中。 然后1当量。 将溴溶解在10mL AcOH中，然后逐滴加入到反应混合物中。 然后将反应在室温下搅拌4小时。 将溶剂蒸发至干，使用正相柱色谱法纯化产物，梯度增加甲醇的二氯甲烷溶液作为洗脱剂。
参考文献：
- [1] Journal of the American Chemical Society, 2000, vol. 122, # 39, p. 9361 - 9366 [2] European Journal of Medicinal Chemistry, 2014, vol. 77, p. 361 - 377 [3] Russian Journal of Applied Chemistry, 2007, vol. 80, # 4, p. 571 - 575 [4] Bioorganic and Medicinal Chemistry, 1997, vol. 5, # 3, p. 601 - 621 [5] Journal of Medicinal Chemistry, 2005, vol. 48, # 24, p. 7520 - 7534 [6] Journal of Medicinal Chemistry, 2014, vol. 57, # 15, p. 6572 - 6582 [7] Chemische Berichte, 1934, vol. 67, p. 1209 [8] Journal of Medicinal Chemistry, 1995, vol. 38, # 2, p. 353 - 358 [9] Journal of Medicinal Chemistry, 1998, vol. 41, # 26, p. 5150 - 5157 [10] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 5, p. 1529 - 1534 [11] Patent: US2007/265265, 2007, A1. Location in patent: Page/Page column 97 [12] Patent: WO2008/64218, 2008, A2. Location in patent: Page/Page column 69 [13] Patent: WO2008/70447, 2008, A2. Location in patent: Page/Page column 72 [14] Patent: WO2005/97746, 2005, A2. Location in patent: Page/Page column 115-116 [15] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 6, p. 2317 - 2326
