体外研究
Ravuconazole shows a broad spectrum of activity against a wide range of fungi covering
Candida spp.
,
Trichosporon beigelii
,
C. neoformans
and
A. fumigatus
. The MIC
90
ranges from 0.025 to 0.39 mg/mL.Ravuconazoleshows relatively higher levels of activity against three strains of
Candida krusei
, with MICs ranging from 0.05 to 0.39 mg/mL.Ravuconazoleshows good activity against
T. mentagrophytes
,
T. rubrum
,
M. gypseum
and
M. canis
with MICs ranging from 0.05 to 0.39 mg/mL. Ravuconazoleis about two- to four fold more potent than itraconazole and about 40-fold more active than fluconazole against yeasts. Ravuconazoleand itraconazoleare inhibitory to most aspergilli, and against half of the isolates, the activity iscidal. Ravuconazoleand itraconazoleare active, though not cidal, against most hyaline
Hyphomycetes
, dermatophytes, and the dematiaceous fungi and inactive against
Sporothrix schenckii
and zygomycetes.
体内研究
The maximum concentration of ravuconazole in plasma and the area under the concentration-time curve for ravuconazoleshow good linearity over a range of doses from 2 to 40 mg/kg of body weight. Ravuconazole at a dose of 2.5 mg/kg delays mortality significantly compared with the control treatment.Ravuconazole also shows a substantial therapeutic effect against systemic cryptococcosis. Ravuconazole reduces the numbers of CFU in the lungs significantly compared with the numbers of CFU in the lungs of the controls. In an experimental model of oral candidiasis in rats, ravuconazole reduces the numbers of CFU in oral swabs significantly compared with the numbers of CFU in oral swabs from the controls and is more effective than itraconazole and as effective as fluconazole..
