化学合成。
化学合成
合成路线 1（1. 合成：875781-41-2）
产率：94%
合成条件：With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at -5 - 0℃; for 1.50 h; Inert atmosphere
实验步骤：向3,5-二溴吡嗪-2-胺（2.00g，7.91mmol）的THF（24mL）溶液中加入三乙胺（3.3mL，24mmol），碘化亚铜（151mg，0.79mmol）和Pd（PPh 3hCh（ 在氮气保护下将混合物冷却至-5℃，然后将三甲基甲硅烷基乙炔（1.07mL，7.50mmol）缓慢滴加到混合物中。加完后，将混合物温热至0℃并搅拌1.5小时。 将混合物真空浓缩以除去溶剂，并将残余物通过硅胶柱色谱法（PE / EtOAc（v / v）= 511）纯化，得到标题化合物，为黑色油状物（42mg，94％）。MS（ ESI，阳离子）m / z：272.00 [M + Ht; 1H NMR（400MHz，CDCh）δ（ppm）：8.04（s，1H），5.14（s，2H），0.30（s，9H）。
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