2491-20-5 L-丙氨酸甲酯盐酸盐

危险性质：非危险化学品 危险品属性：非危险品

化学合成，医药中间体；生命科学。

氨酸甲酯盐酸盐属于氨基酸类衍生物，其可用作氨基酸合成的起始原料，也可用于制备各种含有氨基酸单元的生物活性分子，如多肽、蛋白质等。

合成路线 1（1. 合成：2491-20-5）

产率：100% 合成条件：Stage #1: at -15 - 0℃; Stage #2: for 3 h; Reflux 实验步骤：根据文献，L-丙氨酸用作底物以产生（S） - 丙氨酸甲酯盐酸盐（1a）。 （Xing et al。，2012）。向圆底烧瓶中加入15mL无水甲醇。在-15℃下将2.16mL SOCl 2（0.03mol）缓慢滴加到无水甲醇中并在0℃下保持1小时。用上述步骤将14mL无水甲醇和1.4mL（0.019mol）SOCl2加入另一个圆底烧瓶中。然后，将1.118g L-丙氨酸加入该溶液中并加热回流1.5小时。在减压下浓缩溶液后，将初始制备的SOCl 2溶液倒入圆底烧瓶中并继续回流1.5小时，得到1a（产率100％）。由于在该步骤中产生的盐酸不利于下一步反应，因此当回流结束时将NaHCO 3加入圆底烧瓶中以破坏其酸性，直至不再产生气泡。最后，将溶液浓缩，得到1b（产率100％）。将镰刀菌酸（4）和1b与15mL二氯甲烷一起放入圆底烧瓶中并均匀搅拌，然后加入过量的催化剂二环己基碳二亚胺（DCC）和4-加入二甲基氨基吡啶（DMAP）并回流24小时。在减压下浓缩溶液，并通过使用制备型HPLC（25-45％CH 3 CN / H 2 O，20分钟）纯化产物，得到1c（产率52％）。 参考文献：

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