1034667-22-5 5-氟-1H-吡唑并[3,4-b]吡啶-3-胺

中文名称: 5-氟-1H-吡唑并[3,4-b]吡啶-3-胺
英文名称: 5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine
CAS号

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名称和标识

中文名: 5-氟-1H-吡唑并[3,4-b]吡啶-3-胺
英文名: 5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine
CAS号: 1034667-22-5
分子式: C6H5FN4
分子量: 152.13
中文别名: 3-氨基-5-氟-1H-吡唑[3,4-b]吡啶; 3-氨基-5-氟-1H-吡唑并[3,4-b]吡啶; 5-氟-2H-吡唑并[3,4-b]吡啶-3-胺; 3-氨基-5-氟吡唑并[3,4-b]吡啶
英文别名: 1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro-; 3-Amino-5-fluoro-1H-pyrazolo[3,4-b]pyridine; 5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-ylamine; 5-FLUORO-2H-PYRAZOLO[3,4-B]PYRIDIN-3-AMINE; 3-Amino-5-fluoropyrazolo[3,4-b]pyridine

物化属性

BBB通透性: No
Bioavailability Score: 0.55
CYP1A2抑制剂: Yes
CYP2C19抑制剂: No
CYP2C9抑制剂: No

安全信息

安全说明

危险性质：非危险化学品

生产及用途

用途与制备

化学合成。

化学合成

合成路线 1（1. 合成：1034667-22-5）

产率：88% 合成条件：With hydrazine In butan-1-ol for 4 h; Heating / reflux 实验步骤：向化合物4a（50g，321.7mmol）的1-丁醇（1L）溶液中加入一水合肼（150mL，3.2mol），并将混合物回流4小时。将混合物冷却至室温并浓缩。将沉淀物依次用水（2x）和Et 2 O（2x）洗涤，真空干燥过夜，得到化合物5a（44g，88％），为黄色固体。 1H NMR（DMSO-d6,300MHz）：δ5.53（s，2H）; 7.94（dd，IH）; 8.35（dd，IH）; 12.02（s，IH）。 参考文献：

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