化学合成。
化学合成
合成路线 1（1. 合成：1034667-22-5）
产率：88%
合成条件：With hydrazine In butan-1-ol for 4 h; Heating / reflux
实验步骤：向化合物4a（50g，321.7mmol）的1-丁醇（1L）溶液中加入一水合肼（150mL，3.2mol），并将混合物回流4小时。 将混合物冷却至室温并浓缩。 将沉淀物依次用水（2x）和Et 2 O（2x）洗涤，真空干燥过夜，得到化合物5a（44g，88％），为黄色固体。 1H NMR（DMSO-d6,300MHz）：δ5.53（s，2H）; 7.94（dd，IH）; 8.35（dd，IH）; 12.02（s，IH）。
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