化学合成。
化学合成
合成路线 1(1. 合成:108784-42-5)
产率:4.28 mg
合成条件:With ammonia In water at 70℃; for 2 h; Sealed tube
实验步骤:将3,6-二氟哒嗪(60.3mmol)和25ml氨水在密封管中混合,在70℃下保持反应2小时。冷却后,过滤收集所得沉淀物,然后用水洗涤并干燥,得到 4.28g标题化合物。
参考文献:
- [1] Australian Journal of Chemistry, 1986, vol. 39, # 11, p. 1803 - 1809 [2] Patent: US5049558, 1991, A [3] ACS Medicinal Chemistry Letters, 2010, vol. 1, # 2, p. 80 - 84 [4] Patent: CN103130792, 2016, B. Location in patent: Paragraph 0582-0584 [5] Patent: CN103130791, 2016, B. Location in patent: Paragraph 0406-0408