化学合成。
医药
合成路线 1（1. 合成：158407-04-6）
产率：94%
合成条件：With carbon tetrabromide; triphenylphosphine In dichloromethane at 0 - 20℃; for 22 h;
实验步骤：化合物14; 将EPO N-BOC哌啶-4-甲醇（1g; 46.5mmol）和四溴化碳（1.7g; 51.3mmol）溶解在二氯甲烷（20ml）中并冷却至0℃。 加入三苯基膦（0.98g; 37.3mmol）并将反应在室温下搅拌16小时。 加入另外的三苯基膦（0.4g; 15.7mmol）和四溴化碳（0.24g; 7.2mmol）并继续搅拌6小时。 蒸发溶剂并将残余物在二氧化硅上进行色谱分离。 用20％乙酸乙酯的庚烷溶液（1.22g，94％）洗脱N-BOC哌啶-4-甲基溴。
参考文献：
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