靶点
Target
Value
RSV
(Cell-free assay)
0.86 μM(EC50)
体外研究
RSV604 (5 days) inhibits the growth of four laboratory strains of RSV (RSS, Long, A2 and B), with EC
50
s ranging from 0.5 to 0.9 μM in plaque reduction assay.
RSV604 (6 days) inhibits RSV-induced HEp-2 cell death, with an EC
50
of 0.86 μM.
RSV604 (3 days) reduces viral antigen synthesis in RSV-infected HEp-2 cells, with an EC
50
of 1.7 μM.
RSV604 (1-20 μM; 7 days) dose-dependently inhibits RSV infection in human airway epithelial (HAE) cells, with no gross cytotoxicity, leakage of basolateral fluid to the apical surface, or alteration of cilium beat frequency.
医药
676128-63-5 (S)-1-(2-氟苯基)-3-(2-氧代-5-苯基-2,3-二氢-1H-苯并[e][1,4]二氮杂卓-3-基)脲 - 化工 AI 网
