3-溴-4-氨基苯甲酸乙酯主要作为医药中间体，用于相关药物分子的合成。
医药
合成路线 1（1. 合成：7149-03-3）
产率：91%
合成条件：With N-Bromosuccinimide In N,N-dimethyl-formamide at 0 - 20℃; for 18.50 h; Darkness
实验步骤：向在冰浴中冷却的DMF（150mL）的4-氨基苯甲酸乙酯（10g，61mmol）的溶液中分批加入NBS（10.8g，61mmol），并将混合物在相同温度下搅拌30分钟。 然后移去冰浴并在室温下继续搅拌过夜（18小时）。 将混合物倒入水（500mL）中并过滤，将橙色固体用水（50mL×2）洗涤并从EtOH中重结晶，得到浅黄色晶体（13.3g，91％）Rf = 0.38（PE：EtOAc = 5：1）;熔点 86 - 88°C; 1H-NMR（CDCl3,300MHz）δ：8.07（s，1H），7.79（t，J = 11.55Hz，1H），6.70（d，J = 8.10Hz，1H），4.58（br，2H），4.37 （dd，J = 6.6Hz，J = 6.6Hz，2H），1.34（t，J = 7.2Hz，3H）。
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