302964-08-5 N-(2-氯-6-甲基苯基)-2-[(6-氯-2-甲基-4-嘧啶基)氨基]-5-噻唑甲酰胺

危险性质：非危险化学品

化学合成。

有机合成中间体

合成路线 1（1. 合成：302964-08-5）

产率：98.7% 合成条件：With potassium hydride In tetrahydrofuran at -25 - -10℃; for 4 h; 实验步骤：向冷却至-25℃的80ml四氢呋喃中加入8.73g氢化钾（30重量％，65.38mmol）; 搅拌并搅拌10分钟; 缓慢加入5.00g 2-氨基-N-（2-氯 - 苯基）噻唑-5-甲酰胺，温度为-25℃，加入3.65g含2-甲基的四氢呋喃（7ml）溶液 预先将-4,6-二氯嘧啶加入到反应体系的溶液中，使温度稳定并将反应在-10℃下搅拌4小时。 然后，缓慢加入ImoVL盐酸猝灭反应。 将pH调节至6，控制在0-5℃，结晶2小时，离心，用THF洗涤。粗产物为7.27g。 产率为98.7％，纯度为99.95％（HPLC），最大单杂含量为0.03％ 参考文献：

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