26892-90-0 4-羟基喹啉-3-甲酸乙酯

危险性质：非危险化学品

化学合成。

化学合成

合成路线 1（1. 合成：26892-90-0）

产率：70% 合成条件：Stage #1: at 70℃; for 4 h; Stage #2: With sodium carbonate In water 实验步骤：4-羟基喹啉-3-羧酸乙酯在装有机械搅拌器的1L三颈烧瓶中加入2-苯基氨基亚甲基 - 丙二酸二乙酯（26.3g，0.100mol），多磷酸（270g）和磷酰氯 （750克）。 将混合物加热至70℃并搅拌4小时。 将混合物冷却至室温并过滤。 将残余物用Na 2 CO 3水溶液处理，过滤，用水洗涤并干燥。 得到4-羟基喹啉-3-羧酸乙酯，为浅棕色固体（15.2g，70％）。 参考文献：

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