化学合成。
医药
合成路线 1（1. 合成：134419-59-3）
产率：100%
合成条件：With triethylamine In dichloromethane at 0 - 20℃; for 2.50 h;
实验步骤：实施例32a中间体甲磺酸四氢吡喃-4-基酯的制备在0℃下，向4-羟基四氢吡喃（4.5g，44mmol）（Aldrich）的二氯甲烷（90mL）溶液中加入三乙胺（5.4g，53mmol） ）和甲磺酰氯（3.73mL，48mmol，Aldrich）。 将反应混合物在0℃下搅拌1小时，然后在室温下搅拌1.5小时。 将混合物倒入水中，用二氯甲烷萃取。 分离有机层，用水，盐水洗涤，经MgSO 4干燥，并浓缩，得到粗甲磺酸四氢吡喃-4-基酯，为白色固体（收率8g，100％）。
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