5948-71-0 4-(4-氯苯基)-6-甲基-2-氧代-1,2,3,4-四氢嘧啶-5-羧酸乙酯

未明确提及具体用途，需结合应用领域进一步研究。

医药; 农药

合成路线 1（1. 合成：5948-71-0）

产率：98% 合成条件：With bismuth vanadate In neat (no solvent) at 120℃; for 0.75 h; Green chemistry 实验步骤：一般步骤：将缩氨基脲（1mmol），1,3-二羰基化合物（1mmol），脲（或硫脲）（1.2mmol）和BiVO4-NPs（30mg，9.3mol）在EtOH（2mL）中的混合物搅拌均匀。 回流条件。 在反应完成后（通过TLC监测），将混合物冷却至室温并过滤以分离催化剂。 然后将粗产物从EtOH中重结晶，得到纯产物 参考文献：

• [1] Journal of the Iranian Chemical Society, 2017, vol. 14, # 1, p. 75 - 87 [2] Phosphorus, Sulfur and Silicon and the Related Elements, 2010, vol. 185, # 2, p. 325 - 329 [3] Heteroatom Chemistry, 2007, vol. 18, # 6, p. 684 - 687

合成路线 2（2. 合成：5948-71-0）

产率：100% 合成条件：With copper(II) bis(trifluoromethanesulfonate) In ethanol at 100℃; for 1 h; Microwave irradiation; Inert atmosphere 实验步骤：通用方法：将醛（1.0mmol），乙酰乙酸乙酯（1.0mmol），尿素（1.5mmol），Cu（OTf）2（0.02mmol）和EtOH（2mL）加入装有磁力搅拌棒的微波小瓶中。。 将反应容器密封并在微波反应器（CEM Discover.TM。系统）中在100℃的温度下照射1小时，最大功率为200W。将反应混合物冷却至室温过夜，并将反应混合物冷却至室温。 过滤所得沉淀物并用H 2 O和己烷洗涤。 通过TLC，高分辨率质谱，IR和1H和13C NMR光谱确认产物的特性和纯度 参考文献：

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合成路线 3（3. 合成：5948-71-0）

产率：82% 合成条件：Stage #1: With T 3 P; dimethyl sulfoxide In ethyl acetate at 20℃; Inert atmosphere; Green chemistry Stage #2: at 60 - 70℃; Inert atmosphere; Green chemistry 实验步骤：一般程序：向乙醇（4mL）和DMSO（2mL）的溶剂混合物中的醇（1.0mmol）溶液中加入T3P（2mmol，50％乙酸乙酯溶液），得到的反应混合物 在氮气氛下在室温下搅拌1-2小时。 通过TLC监测反应。 加入β-酮酯/β-氧代硫代酯（1.0mmol）和尿素（1.5mmol）并在60-70℃下再搅拌4-6小时。 反应完成后，蒸发溶剂，将混合物倒入碎冰中。 继续搅拌几分钟。 过滤固体产物，用冷水洗涤，用乙醇重结晶，得到纯产物。 参考文献：

• [1] European Journal of Organic Chemistry, 2015, vol. 2015, # 32, p. 6994 - 6998 [2] Heterocycles, 2005, vol. 65, # 4, p. 767 - 773 [3] Chemistry Letters, 2014, vol. 43, # 2, p. 178 - 180