化学合成。
化学合成
合成路线 1(1. 合成:103260-44-2)
产率:100%
合成条件:at 80℃;
实验步骤:乙基四氢-4H-吡喃-4-基乙酸酯由乙基四氢-4H-吡喃-4-亚基乙酸酯(16.0g,94mmol)和Pd / NH 4 COOH在80℃制备。无色油状物,产率:16.3g,定量),MS: 173.2(M + H)+
参考文献:
- [1] Journal of Medicinal Chemistry, 2004, vol. 47, # 25, p. 6255 - 6269 [2] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 23, p. 6309 - 6323 [3] Patent: US6340691, 2002, B1. Location in patent: Page column 66 [4] Patent: EP1147080, 2004, B1. Location in patent: Page 49 [5] Patent: WO2013/37960, 2013, A1. Location in patent: Page/Page column 76 [6] Journal of Organic Chemistry, 2006, vol. 71, # 26, p. 9909 - 9911 [7] Patent: US2004/220214, 2004, A1 [8] Bioscience, Biotechnology, and Biochemistry, 1994, vol. 58, # 4, p. 647 - 651 [9] Patent: US9481674, 2016, B1. Location in patent: Page/Page column 31; 32 [10] Patent: WO2016/44626, 2016, A1. Location in patent: Paragraph 00484 [11] Patent: EP2737900, 2014, A1. Location in patent: Paragraph 0114; 0116-0117 [12] Justus Liebigs Annalen der Chemie, 1937, vol. 532, p. 80 [13] Chem.Abstr., 1940, p. 4396 [14] Journal of Medicinal Chemistry, 1993, vol. 36, # 16, p. 2300 - 2310 [15] Patent: US2011/144105, 2011, A1. Location in patent: Page/Page column 54 [16] Patent: WO2016/61160, 2016, A1. Location in patent: Paragraph 00105