212322-56-0 3-[(3-氨基-4-甲基氨基苯甲酰)吡啶-2-基氨基]丙酸乙酯

危险性质：非危险化学品

化学合成，医药达比加群中间体。

医药

合成路线 1（1. 合成：212322-56-0）

产率：96% 合成条件：With Raney nickel In tetrahydrofuran at 60℃; Inert atmosphere 实验步骤：（D）中间体VI的制备：在氢化反应烧瓶中，加入43g 3-（4-（甲基氨基）-3-硝基-N-（吡啶-2-基）苯甲酰氨基）丙酸乙酯和4.7g阮内镍500 取4 mL四氢呋喃，氮气置换3次，然后放入氢气中搅拌，加热至60°C反应，进行TLC监测反应; 反应完成，抽滤，用少量四氢呋喃洗涤滤饼; 将滤饼回收并涂抹; 滤液用无水硫酸钠干燥，抽滤，减压浓缩至干，得到38.3g中间体VI（6），收率96％ 参考文献：

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