化学合成。
有机合成; 材料中间体
合成路线 1（1. 合成：56525-79-2）
产率：76%
合成条件：With tetrakis(triphenylphosphine) palladium (0) ; potassium carbonate In tetrahydrofuran; water at 80℃; for 16 h; Inert atmosphere
实验步骤：将其在氮气环境中在700mL四氢呋喃（THF）中溶于3,6-二溴-9H-咔唑（100g，308mmol），此处为苯基硼酸（45.1g，370mmol）并加入四（三苯基膦）钯。 搅拌（10.7g，9.24mmol）。 在饱和水中的碳酸钾（213g，1,540mmol）中，在80℃下加热回流16小时。 反应完成后，将反应溶液加入水中，用DCM萃取，然后用无水MgSO 4除去水，过滤，减压浓缩。 因此，将所得残余物通过快速柱色谱法分离和纯化，得到化合物I-23（74.8g，76％）。
参考文献：
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