1-(3-硝基苯基)乙醇是重要的有机合成中间体，广泛应用于医药和农药领域，可作为多种药物和农药的关键原料。
医药; 农药
合成路线 1（1. 合成：5400-78-2）
产率：98%
合成条件：Stage #1: With nickel boride In water; acetonitrile at 20℃; for 0.08 h; Green chemistry Stage #2: With sodium tetrahydroborate In water; acetonitrile at 20℃; for 0.02 h; Green chemistry
实验步骤：通用程序：在配备有磁力搅拌器的圆底烧瓶（10mL）中，制备硝基苯（0.123g，1mmol）和H 2 O（2mL）的混合物。 然后加入Ni 2 B（0.006g，0.05mmol）并将混合物搅拌5分钟。还加入NaBH 4（0.095g，2.5mmol）并将所得混合物在室温下继续搅拌3分钟。 TLC监测反应进程（洗脱液，正己烷/ Et2O：5/3）。 反应完成后，加入KOH水溶液（2％，5mL）并将混合物搅拌10分钟。 将混合物用EtOAc（3×8mL）萃取，然后用无水Na 2 SO 4干燥。 蒸发溶剂，得到纯液体苯胺，产率95％（0.088g，表2，条目1）。
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